写的:
副总裁，发现生物学，发现科学，R&D、澳门在线赌城娱乐
Vice President, and Head of AstraZeneca's Centre for 基因组学 Research (CGR), 发现 Sciences, R&D、澳门在线赌城娱乐
近年来, the research community has gained considerable knowledge from advances in DNA sequencing combined with novel technologies that are helping us identify gene variants, 因此, 针对慢性疾病的新药物靶点, 预防，甚至有一天可能治愈.
精密医学 – targeting the right medicine to the right patient at the right time – now underpins our approach to drug discovery. 但在澳门第一赌城在线娱乐开始考虑新药之前, it is essential that we grasp the underlying complex biological mechanisms that drive the manifestation, 澳门第一赌城在线娱乐关注的慢性疾病的演变和进展.
Read on to find out how we’re digging deep into disease biology and harnessing data networks and innovative technologies not just to uncover novel drug targets with a higher probability of success, but also to characterise the patient subgroups that are most likely to benefit from treatment innovations.
澳门第一赌城在线娱乐正在从大量的数据中获得新的发现, 应用人工智能, 机器学习和先进的成像技术来加速澳门第一赌城在线娱乐的研究, 创造更能反映人类疾病的生物模型. It’s all part of our ambition to lead the way in a new era of precision medicines for chronic diseases, driving for better patient outcomes and a healthier and more sustainable future for patients and healthcare systems.
从丰富的数据中寻找新的发现
早在2016年，澳门第一赌城在线娱乐就设定了一个大胆的目标，到2026年分析200万个基因组. 这是有史以来最雄心勃勃的测序项目之一, with the aim to uncover new disease insights and expand the therapeutic world that is available to us. Ongoing advances in genome technologies are helping us produce genetic phenotypes of people with chronic diseases based upon their underlying disease mechanisms. This information is key to identifying the most appropriate genetic target for subpopulations of patients.
Our analysis platform is up to 30 times more sustainable than our peers’ platforms helping us explore diseases faster 更有效ly than ever before. 澳门第一赌城在线娱乐正在取得快速进展，已经分析了超过5pb的数据, 识别罕见的基因变异, 发现新的目标, 并与研究界分享澳门第一赌城在线娱乐的见解.
澳门第一赌城在线娱乐现在正在扩大澳门第一赌城在线娱乐的研究，探索DNA之间的关系, RNA和蛋白质在疾病过程中. 通过利用新技术，澳门第一赌城在线娱乐可以调查大量未开发的数据库 multi-omics 更精确的包括:
- 基因组学 -绘制所有人类基因和它们之间的相互作用
- 转录组 -揭示了细胞内哪些基因是开启的，哪些是关闭的
- 蛋白质组学 -决定细胞中表达的蛋白质的类型和数量
- 代谢组学 – provides knowledge of the cellular activities that have taken place based on the metabolites produced
而基因组学提供了一个静态的视角, 其他“组学”是动态的，在不同的条件下会发生变化. They allow us to probe the more complex and transient molecular changes that underpin the course of disease and responses to drug treatment, 创建多维模型的整个层次系统在健康, 患病和治疗状态.
这对药物发现具有深远的影响, 使澳门第一赌城在线娱乐能够发现并验证潜在的新药靶点, anticipate toxicity and identify biomarkers that can be used to develop diagnostic tests to guide treatment in the real world.
加快识别新的疾病靶点
澳门第一赌城在线娱乐正在结合人工智能和机器学习来生产 知识图 它们分析了数十亿的成对关系来显示基因目标之间的联系, 表达与疾病. Knowledge graphs can reveal unexplored patterns of disease and are considered less biased than most other approaches used in target identification due to the breadth of information they capture. 它们还会随着新信息的加入而不断发展, creating a ‘living map’ of a disease which we can interrogate to identify novel disease targets. 一个人永远无法单独达到这种分析和洞察力的水平, 即使在他们的整个职业生涯中都在扎实地工作!
创造更能反映人类疾病的生物模型
一旦澳门第一赌城在线娱乐确定了可能导致某种疾病的基因, 澳门第一赌城在线娱乐在一个相关的生物学模型中检查它的功能. 澳门第一赌城在线娱乐的科学家, 以及澳门第一赌城在线娱乐在BenevolentAI的合作伙伴, 是否在2021年使用功能基因组学方法确定了五个新的药物靶点.
A key technology we’re using within Functional 基因组学 is CRISPR/Cas9 gene editing which introduces specific changes into genes – removing, 增加, 或者改变DNA密码，以反映患病状态下发生的相同遗传变化. Using CRISPR we can more closely reproduce the real-life environment and test if our drug candidates achieve the desired response.
在澳门第一赌城在线娱乐利用这项技术之前, it would have taken months if not years to produce cell lines; today we can produce them in a matter of weeks. This gives us new opportunities to target the gene variants that we suspect are involved in disease.
利用先进的成像技术，更清楚地看到慢性病
Advanced imaging technologies are uncovering the cellular processes that define a disease at a molecular level. 澳门第一赌城在线娱乐正在利用这些先进技术，并将其用于澳门第一赌城在线娱乐的临床试验, 重新定义终点以证明靶向治疗对疾病的改善.
Through our collaboration with the University of Southampton we’re gaining a better understanding of the processes involved in chronic obstructive pulmonary fibrosis (COPD), 一种限制肺部气流的炎症状况. Our researchers have used advanced imaging to compare two computerised tomography (CT) techniques and assess their relationship with specific physiological measures of small airways disease. The new techniques can detect disease more effectively than traditional scanning methods and as a result are now being incorporated into our clinical trial design to measure the effect of our targeted precision medicines.
加快为慢性病患者创造更美好的未来
精密医学 will revolutionise the way we understand, classify and treat chronic diseases. 它提供了更精确的诊断, 对疾病易感性的早期识别, 更有效, 针对患者的针对性医疗保健干预措施.
We have successfully used precision medicine to select top drug candidates to progress through clinical development, 澳门第一赌城在线娱乐80%的澳门第一赌城在线娱乐产品线现在都采用了精准医疗方法. 通过在澳门第一赌城在线娱乐的研究和开发中利用新技术, 澳门第一赌城在线娱乐希望提高药物发现的效率, 帮助改善世界各地慢性病的预后.
